3D printing .. the patient makes the medicine

Recently, 3D printing technology has attracted a lot of attention of scientists and researchers in the field of pharmaceutical sciences and pharmaceutical industry over the last ten years. In particular, after the US Food and Drug Administration (FDA) approved in 2015, the production of the drug “Spritam” for Aprecia Pharmaceuticals, which is used to treat epileptic seizures. This drug is the first drug produced in printed form through 3D printing technology. With this technology, a new chapter opens and a great revolution in the field of personalized medicine, which depends on the production of a model of medicine that adapts to the dose, size and shape to adapt to the disease state of each patient.

pharmacokinetic fingerprints

Scholarship student Abdullah Al-Zahrani, a researcher in pharmaceutical sciences at the University of Mississippi in the United States, and winner of the University Award for Academic Achievement for 2022, indicated that the adoption of such technology will provide a qualitative leap in the field of pharmaceutical industries by increasing the degree of suitability of the pharmaceutical formula. He added that it is possible in the future to design the drug according to the age, weight and condition of the patient and then print the drug for each patient separately, in a step closer to what can be called (grass fingerprint) . according to his data, the patient is printed the appropriate drug.

Al-Zahrani showed that this technology will help hospitals, clinics and pharmacies in remote areas to find the most efficient and easy sweets, and can also be used in the field of clinical studies by designing specific and appropriate doses for each case of illness.

cumulative production technology

Al-Zahrani added that 3D printing technology for drugs is one of the cumulative production techniques, which depends on the principle of layer-by-layer printing – through which the layers of the drug are produced and constructed by creating a number of layers on the printer design plate. . Cumulative manufacturing technology has many advantages over the traditional production methods currently used in global pharmaceutical factories.

Advantages of oppressive medicine

He showed that the use of 3D printing technology has a number of advantages in the field of drug production and efficiency methods for patients. One of these advantages is the ability of this technology to deliver the active substance of the drug to a specific location of the printed drug to control the absorption of the drug into the body at the most appropriate time. Also, this 3D printing technology helps in the process of determining the sizes and shapes of the drugs, no matter how small the medicine or the type of form in which it ends up. These processes were preceded by work on drug programming and design through a series of design processing programs, prior to the start of final drug printing. Moreover, 3D printing technology facilitates the process of combining the active substances of drugs into one tablet, and in some cases, the process of combining more than 5 drugs into one tablet, which is known as the concept of “multi-pharmacy” or (poly-pharmacy). ), which is a qualitative step in the process of providing medication and facilitating their receipt by patients, without having to take many types of medications scientifically known as (patient compliance).

Uses of 3D printing

In one of the specialized researches he conducted in the field of development of several drugs and pharmaceutical forms using this technology, Al-Zahrani succeeded in improving and developing a combined drug of two active substances (fixed dose combination) used in the treatment of high blood pressure. pressure. In his speech to Al-Watan newspaper, he showed that the result of combining this into a printed smart tablet increased the ability to dynamically control the dose of the drug and the pharmaceutical form of the drug. It is worth noting that researcher Al-Zahrani, in another scientific study, developed a printed chip containing an antibiotic, placed inside the eye (ocular insert) that is used at a rate of two points every 15 minutes to treat cases of inflammation. acute of the eye. Possibility of using the printed medicine chip directly on the surface of the cornea of ​​the eye, sucking the medicine for a period of 24 hours, instead of using the eye drops more than once.

The future of 3D printing technology

He stressed that if this technology is fully approved by the pharmaceutical legislatures in the United States and European bodies and a consensus formula is reached to regulate the pharmaceutical industry using this technology in pharmaceutical companies and factories, once the quality and quality standards are achieved and ensured. security, ministries of health will help empower hospitals.Health clinics, emergency rooms and pharmacies can print some medicines through this technology for immediate use purposes (immediate consumption) for the benefit of the patient and humanity. Al-Zahrani stressed that the technology of manufacturing medicines using 3D printing technology at home is possible, but there is still a need for more scientific research in this area to ensure the safety of medicines for the patient.

Types of 3D printers used in medical and drug research:

Modeling of FDM fused deposition

Photopolymerization of VAT

Extraction of thermal softening material

Fusion bed powder

Explosion of raster material

SLS for selective laser laser sintering 3D

SLA 3D stereolithography

Therapeutic disk with 3D technology

Therapeutic discs of different sizes

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